MR-link and genome_integration

Contents:

• Introduction
• Structure of the package
• Requirements
• Installation
• Running MR-link
• Simulation of genotypes and phenotypes for MR-link
• Calibrating MR-link p values
• The genome_integration package
• module: genome_integration.variants
• module: genome_integration.samples
• module: genome_integration.gene_regions
• module: genome_integration.association
• module: genome_integration.causal_inference
• module: genome_integration.simulate_mr
• module: genome_integration.resources
• module: genome_integration.utils

Introduction

This package contains MR-link, a Mendelian randomization (MR) method that efficiently identifies causal relationships between gene expression and complex traits, implicitly correcting for unobserved pleiotropy even if there is only one single instrumental variable available.

The source code of the package can be found at github

genome_integration is the library and ./mr_link/ has the programs for an implementation of MR-link.

For more information please read our preprint